Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC et al the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Epidemiology of bronchopulmonary dysplasia. However, further studies with larger sample sizes are needed to delineate the possible link between vitamin D deficiency and BPD. We demonstrated for the first time that lower maternal and neonatal vitamin 25-OHD levels were associated with BPD development in preterm infants. Univariate logistic regression analysis revealed that maternal/neonatal vitamin D levels were a significant predictor of BPD (odds ratio (OR): 0.76 and 0.61, respectively, P<0.001). All of the infants with BPD had a 25-OHD level <10 ng ml −1, which represented severe deficiency. A positive correlation was detected between maternal and neonatal 25-OHD levels. Both maternal and neonatal 25-OHD levels in the BPD group were significantly lower compared with those in the no-BPD group ( P=0.0001). Result:Ī total of 100 infants were included and 31 (31%) developed bronchopulmonary dysplasia (BPD). 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit. One hundred and thirty-two preterm infants ⩽32 weeks of gestation who were diagnosed with respiratory distress syndrome were enrolled. The objective of this study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of bronchopulmonary dysplasia.
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